The U.S. Department of Education (ED) was established in 1979 by President Jimmy Carter to ensure equal educational opportunities for all students and streamline federal education policies. Before its creation, education oversight was scattered across multiple agencies, leading to inefficiencies and inconsistencies in funding and policy implementation.

The Centers for Disease Control and Prevention (CDC) has been a cornerstone of public health in the United States since its founding in 1946. Originally established as the Communicable Disease Center, its primary mission was to combat malaria, which posed a significant threat in the southern U.S. at the time. Armed with a small budget and a dedicated team, the CDC focused on controlling mosquito populations and preventing the spread of disease.

The United States Agency for International Development (USAID) was established by President John F. Kennedy in 1961, consolidating various foreign assistance programs into a single agency. Its mission was to promote international development while advancing U.S. foreign policy objectives, rooted in the belief that America's security and prosperity were linked to the wellbeing of developing nations.